Kaikaifilu is an extinct genus of tilosaurine mosasaur reptile that lived during the Upper Cretaceous in Antarctica, just before the Cretaceous-Tertiary mass extinction. It is one of the largest members of the tilosaurs, a group of marine lizards that lived during the Cretaceous.
In 2011, the Chilean Paleontological Expedition collected a large mosasaur skull, associated jaw fragments, a partial humerus, and about 30 isolated teeth from the upper layers of the Lopez de Bertodano Formation on Seymour Island, Antarctica. The specimen, cataloged as SGO.PV.6509, was found in rocks dating from the late Maastrichtian era, about 200 meters below the Cretaceous-Paleogene boundary.